What is a key function of dicer in RNA interference?

Study for the University of Toronto BIO230H1 Midterm Exam. Grasp complex concepts with interactive questions and detailed explanations. Prepare effectively to excel in your exam!

Dicer is an essential enzyme in the RNA interference (RNAi) pathway, playing a crucial role in the processing of double-stranded RNA (dsRNA). Its primary function is to cleave long dsRNA precursors into shorter interfering RNA molecules called small interfering RNAs (siRNAs). This process is critical for the initiation of the RNAi mechanism, as these siRNAs are subsequently incorporated into the RNA-induced silencing complex (RISC). Once inside RISC, the siRNAs guide the complex to complementary mRNA targets, leading to mRNA degradation or translational repression, thereby regulating gene expression.

While other functions are important in the broader context of RNA interference, they do not accurately describe the specific role of Dicer. For instance, splicing mRNA pertains to a different cellular process entirely, involving pre-mRNA splicing regulated by spliceosomes. The destruction of dsRNA is not a direct function of Dicer; rather, it processes dsRNA to generate siRNAs. Recruiting modifying enzymes is another vital aspect of gene regulation but does not specifically relate to the function of Dicer in producing siRNAs. Thus, the key function of Dicer in RNA interference is the production of siRNAs, which are crucial for the silencing of genes

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