Is the statement "GTP hydrolysis causes a conformation change in eIF3" true or false?

The statement that "GTP hydrolysis causes a conformation change in eIF3" is true. GTP (guanosine triphosphate) hydrolysis is a critical step in many molecular processes within the cell, particularly in translation initiation. The eukaryotic initiation factor 3 (eIF3) is a complex involved in the initiation of protein synthesis. Upon GTP hydrolysis, the structural changes that occur in GTP-bound proteins, including eIF3's interactions with other initiation factors and the ribosome, facilitate the proper assembly of the translation initiation complex.

While the mechanisms and molecular players may vary between prokaryotes and eukaryotes, the fundamental role of GTP hydrolysis in inducing conformational changes in initiation factors and influencing translation initiation is a significant concept. Hence, eIF3 experiences conformation changes upon GTP hydrolysis, aligning with what is understood about its function in eukaryotic translation initiation.

This understanding underscores the importance of GTP hydrolysis in modulating the activity of key components of the translation machinery, reinforcing the idea that hydrolysis leads to necessary adjustments in the protein complexes for proper function.