Which of the following describes the import of proteins to mitochondria?

Study for the University of Toronto BIO230H1 Midterm Exam. Grasp complex concepts with interactive questions and detailed explanations. Prepare effectively to excel in your exam!

The correct choice highlights the essential role of the TOM (Translocase of the Outer Membrane) and TIM23 (Translocase of the Inner Membrane) complexes in the import of proteins into mitochondria. Proteins destined for the mitochondria are generally synthesized in the cytosol and contain specific signal sequences that direct their transport to the mitochondria. Once these proteins reach the mitochondrion's outer membrane, the TOM complex facilitates their entry into the intermembrane space. From there, the TIM23 complex is crucial for translocating the proteins into the mitochondrial matrix or integrating them into the inner membrane.

The requirement for these translocase complexes is central to the import process, as they provide the necessary mechanisms to ensure that proteins are correctly imported and placed in their functional locations within the mitochondrion. This is a well-established aspect of mitochondrial biology and underlines the intricate nature of protein import mechanisms. Therefore, the involvement of both TOM and TIM23 is fundamental to understanding how mitochondria acquire the proteins required for their functions from the cytosol.

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